Novel cytocidal antibiotics, glucopiericidinols A1 and A2 Taxonomy, fermentation, isolation, structure elucidation and biological characteristics.
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چکیده
منابع مشابه
Novel antibiotics, furaquinocins A and B. Taxonomy, fermentation, isolation and physico-chemical and biological characteristics.
Two novel antibiotics, furaquinocins A and B were isolated from the culture broth of Streptomyces sp. KO-3988. These antibiotics possess cytocidal activities against HeLa S3 cells in vitro at concentrations of 3.1 micrograms/ml for A and 1.6 micrograms/ml for B. Neither substance possessed antimicrobial activities against Gram-positive and Gram-negative bacteria, fungi or yeast at a concentrati...
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A fermentation broth of an unidentified fungus (N983-46) was found to produce DNAgyrase inhibitors, CJ-12,371 (1) and CJ-12,372 (2). Following isolation by solvent extraction and silica gel and ODS(reverse phase) chromatographies, the structures were determined to be novel spiro-ketal compounds with S-connguration at position C-l. CJ-12,371 and CJ-12,372 inhibit both DNA supercoiling and relaxa...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1989
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.42.1734